A Stream Processing System for Multisource Heterogeneous Sensor Data

With the rapid development of the Internet of Things (IoT), a variety of sensor data are generated around everyone’s life. New research perspective regarding the streaming sensor data processing of the IoT has been raised as a hot research topic that is precisely the theme of this paper. Our study serves to provide guidance regarding the practical aspects of the IoT. Such guidance is rarely mentioned in the current research in which the focus has been more on theory and less on issues describing how to set up a practical system. In our study, we employ numerous open source projects to establish a distributed real time system to process streaming data of the IoT. Two urgent issues have been solved in our study that are (1) multisource heterogeneous sensor data integration and (2) processing streaming sensor data in real time manner with low latency. Furthermore, we set up a real time system to process streaming heterogeneous sensor data from multiple sources with low latency. Our tests are performed using field test data derived from environmental monitoring sensor data collected from indoor environment for system validation. The results show that our proposed system is valid and efficient for multisource heterogeneous sensor data integration and streaming data processing in real time manner

Materials, Preparation Strategies, and Wearable Sensor Applications of Conductive Fibers: A Review

The recent advances in wearable sensors and intelligent human–machine interfaces have sparked a great many interests in conductive fibers owing to their high conductivity, light weight, good flexibility, and durability. As one of the most impressive materials for wearable sensors, conductive fibers can be made from a variety of raw sources via diverse preparation strategies. Herein, to offer a comprehensive understanding of conductive fibers, we present an overview of the recent progress in the materials, the preparation strategies, and the wearable sensor applications related. Firstly, the three types of conductive fibers, including metal-based, carbon-based, and polymer-based, are summarized in terms of their principal material composition. Then, various preparation strategies of conductive fibers are established. Next, the primary wearable sensors made of conductive fibers are illustrated in detail. Finally, a robust outlook on conductive fibers and their wearable sensor applications are addressed

Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Abeta aggregation in SH-SY5Y cells

Alzheimer\u2019s disease (AD) is a common form of neurodegenerative disease. Mounting evidence suggests that metal ions play a key role in the aggregation of amyloid \u3b2 peptide (A\u3b2), which acts as a factor or cofactor in the etiopathogenesis of AD. Therefore, inhibition of A\u3b2 aggregation emerges as a potential approach for the treatment of AD. We have found that baicalin can interact with copper directly and inhibits A\u3b2 1\u201342 aggregation. In addition, baicalin protects SH-SY5Y cells from oxidative injuries induced by A\u3b2 1\u201342 aggregation through decreasing H2O2 production that is normally formed as a deleterious byproduct of beta amyloid aggregation and the formation of plaques. Taken together, these data indicate that baicalin may be a potential agent to inhibit A\u3b2 aggregation and thereby delay, mitigate or modify the progression of neurodegenerative diseases such as AD.Peer reviewed: YesNRC publication: Ye

Silibinin: A novel inhibitor of A\u3b2 aggregation

Alzheimer's disease (AD) is characterized by the abnormal aggregation of amyloid \u3b2 peptide (A\u3b2) into extracellular fibrillar deposits known as amyloid plaque. Inhibition of A\u3b2 aggregation is therefore viewed as a potential method to halt or slow the progression of AD. It is reported that silibinin (silybin), a flavonoid derived from the herb milk thistle (Silybum marianum), attenuates cognitive deficits induced by A\u3b225-35 peptide and methamphetamine. However, it remains unclear whether silibinin interacts with A\u3b2 peptide directly and decreases A\u3b2 peptide-induced neurotoxicity. In the present study, we identified, through employing a ThT assay and electron microscopic imaging that silibinin also appears to act as a novel inhibitor of A\u3b2 aggregation and this effect showed dose-dependency. We also show that silibinin prevented SH-SY5Y cells from injuries caused by A\u3b21-42-induced oxidative stress by decreasing H2O2 production in A\u3b21-42-stressed neurons. Taken together, these results indicate that silibinin may be a novel therapeutic agent for the treatment of AD.Peer reviewed: YesNRC publication: Ye

Generation of male germ cells from mouse induced pluripotent stem cells in vitro

Germ cells are the only cell type that passes genetic information to the next generation. In most metazoan species, primordial germ cells (PGCs) were induced from epiblasts by signals from the neighboring tissues. In vitro derivation of germ cells from the pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) and induced PSCs (iPSCs) are of great values for the treatment of infertility, for animal breeding, and for studying the mechanism of germ cell development. Although the derivations of male germ cells from PSCs have been previously reported, most of the studies failed to conduct the induction in a well-controlled and highly efficient manner. Here, we report the derivation of induced PGC-like cells (iPGCLCs) from mouse iPSCs via induced epiblast-like cells (iEpiLCs) as being monitored by the expression of enhanced green fluorescent protein gene under the control of the promoter of stimulated by retinoic acid 8 (Stra8-EGFP). The identity of iPGCLCs was characterized by examining the expression of multiple marker genes as well as by the recovery of spermatogenesis after they were transplanted to the testis of infertile W/Wv mice. Furthermore, iPGCLCs were either induced to germline stem cell-like cells (iGSCLCs) or reverted back to embryonic germ cell-like cells (iEGCLCs). In conclusion, we have established an efficient procedure for inducing iPSCs into iPGCLCs that can be further expanded and induced to more developed germ cells. This work indicates that the technology of in vitro germ cell induction is becoming more sophisticated and can be further improved

Prodigiosin found in Serratia marcescens y2 initiates phototoxicity in the cytomembrane

Background: Light can be absorbed by bacterial pigment and affects its growth. Prodigiosin is a red pigment found in various bacterial species. The purpose of this study was to investigate the impacts of light on prodigiosin production, biomass formation, and membrane integrity of Serratia marcescens y2